Skip Navigation
Skip to contents

Epidemiol Health : Epidemiology and Health

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Search

Page Path
HOME > Search
4 "Heejin Kimm"
Filter
Filter
Article category
Keywords
More +
Publication year
Authors
More +
Funded articles
Original Articles
Prediction of cancer survivors’ mortality risk in Korea: a 25-year nationwide prospective cohort study
Yeun Soo Yang, Heejin Kimm, Keum Ji Jung, Seulji Moon, Sunmi Lee, Sun Ha Jee
Epidemiol Health. 2022;44:e2022075.   Published online September 13, 2022
DOI: https://doi.org/10.4178/epih.e2022075
  • 4,536 View
  • 141 Download
  • 1 Web of Science
  • 2 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
This study aimed to investigate the factors affecting cancer survival and develop a mortality prediction model for Korean cancer survivors. Our study identified lifestyle and mortality risk factors and attempted to determine whether health-promoting lifestyles affect mortality.
METHODS
Among the 1,637,287 participants in the Korean Cancer Prevention Study (KCPS) cohort, 200,834 cancer survivors who were alive after cancer diagnosis were analyzed. Discrimination and calibration for predicting the 10-year mortality risk were evaluated. A prediction model was derived using the Cox model coefficients, mean risk factor values, and mean mortality from the cancer survivors in the KCPS cohort.
RESULTS
During the 21.6-year follow-up, the all-cause mortality rates of cancer survivors were 57.2% and 39.4% in men and women, respectively. Men, older age, current smoking, and a history of diabetes were high-risk factors for mortality, while exercise habits and a family history of cancer were associated with reduced risk. The prediction model discrimination in the validation dataset for both KCPS all-cause mortality and KCPS cancer mortality was shown by C-statistics of 0.69 and 0.68, respectively. Based on the constructed prediction models, when we modified exercise status and smoking status, as modifiable factors, the cancer survivors’ risk of mortality decreased linearly.
CONCLUSIONS
A mortality prediction model for cancer survivors was developed that may be helpful in supporting a healthy life. Lifestyle modifications in cancer survivors may affect their risk of mortality in the future.
Summary
Korean summary
현재 암 생존자의 사망 위험을 평가하는 데 유용한 한국형 암 생존자 사망률 예측 모델은 없습니다. 본 연구에서는 고령, 남성, 현재 흡연, 당뇨병 병력을 포함한 생활양식 요인이 사망의 고위험 요인인 반면, 운동 습관 및 암의 가족력은 사망 위험을 감소시키는 것으로 나타났습니다. 현재 흡연과 운동 습관은 사망 위험에 영향을 미치는 수정 가능한 두 가지 요소로써, 이러한 생활습관 요인으로 구성된 예측모형은 생활습관 교정을 통해 우리나라 암 생존자의 사망률을 낮출 수 있음을 시사합니다.
Key Message
Currently, there is no Korean mortality prediction model for cancer survivors that would be useful in evaluating their risk of mortality. The present study showed that lifestyle factors, including older age, male sex, current smoking, and history of diabetes were high-risk factors for mortality, while exercise habits and a family history of cancer reduced the risk of mortality. Current smoking and exercise habits are the two modifiable factors that affected the risk of mortality. The prediction model comprising these lifestyle factors implies that the risk of mortality of cancer survivors in Korea can be reduced through lifestyle modification.

Citations

Citations to this article as recorded by  
  • COVID-19 Mortality and Severity in Cancer Patients and Cancer Survivors
    Jae-Min Park, Hye Yeon Koo, Jae-ryun Lee, Hyejin Lee, Jin Yong Lee
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Weight maintenance and gain were significantly associated with lower risk of all-cause and cancer-related mortality in Korean adults who were newly diagnosed with cancer based on the Korean NHIS-HEALS cohort
    Yong-June Kim, Seung Park, Won Tae Kim, Yoon-Jong Bae, Yonghwan Kim, Hee-Taik Kang
    Medicine.2023; 102(47): e36184.     CrossRef
Bilirubin and risk of ischemic heart disease in Korea: a two-sample Mendelian randomization study
Christina Jeon, Ji-Young Lee, Sun Ju Lee, Keum Ji Jung, Heejin Kimm, Sun Ha Jee
Epidemiol Health. 2019;41:e2019034.   Published online July 12, 2019
DOI: https://doi.org/10.4178/epih.e2019034
  • 11,678 View
  • 284 Download
  • 10 Web of Science
  • 10 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
Bilirubin is an endogenous antioxidant that protects cells against oxidative stress. Increased plasma levels of bilirubin have been associated with a reduced risk of ischemic heart disease (IHD) in previous studies. Nonetheless, whether those associations reflect a true protective effect of bilirubin on IHD, rather than confounding or reverse causation, remains unknown. Therefore, we applied two-sample Mendelian randomization to evaluate the causal association between bilirubin levels and IHD risk in a Korean population.
METHODS
A total of 5 genetic variants—TRPM8 (rs10490012), USP40 (rs12993249), ATG16L1 (rs2119503), SLCO1B1 (rs4149014), and SLCO1B3 (rs73233620)—were selected as genetic instruments for serum bilirubin levels using a communitybased cohort, the Korean Genome and Epidemiology Study, comprising 33,598 subjects. We then evaluated their impact on IHD using the Korean Cancer Prevention Study-II cohort.
RESULTS
Among the 5 instrumental variables that showed significant associations with serum bilirubin levels, rs12993249 (USP40) showed the most significant association (p<2.36×10-105). However, we found no significant association between serum bilirubin levels and IHD. Sensitivity analyses demonstrated a consistent association, suggesting that our observations were robust.
CONCLUSIONS
Using two-sample Mendelian randomization, we found no association between serum bilirubin levels and IHD. Further studies that confirm the observed interactions among other ethnicities are warranted.
Summary
Korean summary
이 연구는 대규모 한국인 코호트를 이용하여, 빌리루빈과 허혈성 심장질환의 인과성을 규명한 연구결과이다. 특히 두 가지 자료를 이용한 멘델리안 무작위배정 연구방법을 적용하여, 한국인을 대상으로 빌리루빈과 허혈성 심장질환의 인과성을 처음으로 규명한 점이 큰 시사점을 가진다.

Citations

Citations to this article as recorded by  
  • Association of Different Total Bilirubin Levels with Prognosis of Peritoneal Dialysis-Associated Peritonitis
    Yujian He, Jingjing Zhu, Fei Xiao, Qingyun Luo, Pengpeng Wang, Xu Wang, Yan He, Zibo Xiong
    Medicina.2023; 59(10): 1837.     CrossRef
  • Novel prognostic score based on the preoperative total bilirubin-albumin ratio and fibrinogen-albumin ratio in ampullary adenocarcinoma
    Xiao-Jie Zhang, He Fei, Chong-Yuan Sun, Ze-Feng Li, Zheng Li, Chun-Guang Guo, Dong-Bing Zhao
    World Journal of Gastrointestinal Surgery.2023; 15(10): 2247.     CrossRef
  • SLCO1B1 variants and the risk of antituberculosis drug-induced hepatotoxicity: a systematic review and meta-analysis
    Min Zhu, Xinyu Chen, Zhuolu Hao, Yiwen He, Bing Han, Shaowen Tang
    Pharmacogenomics.2023; 24(18): 931.     CrossRef
  • The Nonlinear Relationship Between Total Bilirubin and Coronary Heart Disease: A Dose-Response Meta-Analysis
    Chaoxiu Li, Wenying Wu, Yumeng Song, Shuang Xu, Xiaomei Wu
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Another Reason to Cut Down on Alcohol?
    Hyeon Chang Kim
    Korean Circulation Journal.2022; 52(3): 231.     CrossRef
  • Serum bilirubin and kidney function: a Mendelian randomization study
    Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
    Clinical Kidney Journal.2022; 15(9): 1755.     CrossRef
  • Heme Oxygenase-1 and Blood Bilirubin Are Gradually Activated by Oral D-Glyceric Acid
    O. Petteri Hirvonen, Maarit Lehti, Heikki Kyröläinen, Heikki Kainulainen
    Antioxidants.2022; 11(12): 2319.     CrossRef
  • Exploring the causal pathway from bilirubin to CVD and diabetes in the UK biobank cohort study: Observational findings and Mendelian randomization studies
    Lei Hou, Hongkai Li, Shucheng Si, Yuanyuan Yu, Xiaoru Sun, Xinhui Liu, Ran Yan, Yifan Yu, Chuan Wang, Fan Yang, Qing Wang, Fuzhong Xue
    Atherosclerosis.2021; 320: 112.     CrossRef
  • The causal association of bilirubin with cardiovascular disease: Are there still any questions?
    Claudia Lamina, Florian Kronenberg
    Atherosclerosis.2021; 320: 92.     CrossRef
  • Association between Alcohol Consumption and Serum Cortisol Levels: a Mendelian Randomization Study
    Jung-Ho Yang, Sun-Seog Kweon, Young-Hoon Lee, Seong-Woo Choi, So-Yeon Ryu, Hae-Sung Nam, Kyeong-Soo Park, Hye-Yeon Kim, Min-Ho Shin
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
Relationship between binge drinking experience and suicide attempts in Korean adolescents: based on the 2013 Korean Youth Risk Behavior Web-based Survey
Kyeong Hyang Byeon, Sun Ha Jee, Jae Woong Sull, Bo Young Choi, Heejin Kimm
Epidemiol Health. 2018;40:e2018046.   Published online September 26, 2018
DOI: https://doi.org/10.4178/epih.e2018046
  • 12,667 View
  • 184 Download
  • 10 Web of Science
  • 13 Crossref
AbstractAbstract PDFSupplementary Material
Abstract
OBJECTIVES
Suicide and drinking problems in adolescents are increasing every year, and it is known that suicide is related to drinking. This study aims to identify the relationship between binge drinking experience (BDE) and suicide attempts in Korean adolescents.
METHODS
The Ninth Korean Youth Risk Behavior Web-based Survey (KYRBS), conducted in 2013, was used for analysis. Multiple logistic regression analysis was used to identify the relationship between BDE and suicide attempts, and the relationship between BDE and suicide attempts in middle and high school students was stratified by age.
RESULTS
BDE and suicide attempts were highly related. The odds ratio (OR) of attempted suicide in BDE was 1.63 times (95% confidence interval [CI], 1.28 to 2.09) higher then non-drinking in males. And the OR of attempted suicide in females was 1.21 times (95% CI, 1.07 to 1.37) higher then non-drinking in non-BDE, 1.79 times (95% CI, 1.47 to 2.19) higher in BDE. BDE was associated with suicide attempts in males aged 12 or 13 years (OR, 3.97; 95% CI, 1.57 to 10.03) and in females aged 15 years (OR, 2.66; 95% CI, 1.79 to 3.96).
CONCLUSIONS
BDE is an important factor related to suicide attempts in adolescents. In order to reduce suicide attempts, it is necessary to educate the youth about the regulation of BDE and drinking prevention.
Summary

Citations

Citations to this article as recorded by  
  • Binge Drinking and its Relationship with Suicidal Thoughts and Suicidal Attempts in University Students
    Pablo Juan-Salvadores, Luis Mariano de la Torre Fonseca, Antía Lafuente Pérez, Cesar Veiga, José A. González-Nóvoa, Andrés Iñiguez Romo, Francisco Caamaño Isorna, Víctor Alfonso Jiménez Díaz
    International Journal of Mental Health and Addiction.2024;[Epub]     CrossRef
  • Prevalence and associated factors of binge drinking among high school students in Acapulco, Mexico: a cross-sectional study
    Abel Emigdio-Vargas, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Alfonso Dávalos-Martínez, Nubia Blanco-García, Elia Barrera-Rodriguez, Liliana Morales-Nava, Neil Andersson
    Drugs: Education, Prevention and Policy.2023; 30(6): 603.     CrossRef
  • Binge drinking and suicidal ideation in Peruvian adolescents: Evidence from a pooled cross-sectional survey
    Akram Hernández-Vásquez, Rodrigo Vargas-Fernández, Guido Bendezu-Quispe
    Journal of Affective Disorders.2023; 340: 321.     CrossRef
  • Is Binge Drinking Associated with Suicidal Behaviors among Brazilian Adolescents?
    Thaise Queiroz de Melo, Delmilena Maria Ferreira de Aquino, Alisse Maria Chaves de Lima Peixoto, Jonathan Lopes de Lisboa, Raquel Conceição Ferreira, Patricia Maria Pereira de Araújo Zarzar, Viviane Colares, Fabiana de Godoy Bene Bezerra Laureano, Carolin
    Substance Use & Misuse.2022; 57(9): 1365.     CrossRef
  • Disparity between Subjective Health Perception and Lifestyle Practices among Korean Adolescents: A National Representative Sample
    Aniceto Echalico Braza, Jinsoo Jason Kim, Sun Hee Kim
    Journal of Lifestyle Medicine.2022; 12(3): 153.     CrossRef
  • Impulsivity and Impulsivity-Related Endophenotypes in Suicidal Patients with Substance Use Disorders: an Exploratory Study
    Alessandra Costanza, Stéphane Rothen, Sophia Achab, Gabriel Thorens, Marc Baertschi, Kerstin Weber, Alessandra Canuto, Hélène Richard-Lepouriel, Nader Perroud, Daniele Zullino
    International Journal of Mental Health and Addiction.2021; 19(5): 1729.     CrossRef
  • Association between sleep insufficient type and suicidal ideation among Korean middle and high school student
    Soojeong Kim, Jin A Han, Eun-Ji Kim, Soon Young Lee
    Korean Journal of Health Education and Promotion.2021; 38(2): 15.     CrossRef
  • Association Between Suicide and Drinking Habits in Adolescents
    Ji Won Lee, Bong-Jo Kim, Cheol-Soon Lee, Boseok Cha, So-Jin Lee, Dongyun Lee, Jiyeong Seo, Young-Ji Lee, Youn-Jung Lee, Eunji Lim, Jae-Won Choi
    Journal of the Korean Academy of Child and Adolescent Psychiatry.2021; 32(4): 161.     CrossRef
  • Victimization as a mediator in the relationship between sexual orientation and adolescent alcohol use
    Ji-Su Kim, Yeji Seo
    Archives of Psychiatric Nursing.2020; 34(1): 27.     CrossRef
  • Suicide Attempts and Contributing Factors among South and North Korean-Family Youth Using the Korean Youth Risk Behavior Web-based Survey
    Soo Jung Rim, Min Geu Lee, Subin Park
    Journal of the Korean Academy of Child and Adolescent Psychiatry.2020; 31(1): 33.     CrossRef
  • Associations between Gender, Alcohol Use and Negative Consequences among Korean College Students: A National Study
    Patrick Allen Rose, Hugh Erik Schuckman, Sarah Soyeon Oh, Eun-Cheol Park
    International Journal of Environmental Research and Public Health.2020; 17(14): 5192.     CrossRef
  • Prediction models for high risk of suicide in Korean adolescents using machine learning techniques
    Jun Su Jung, Sung Jin Park, Eun Young Kim, Kyoung-Sae Na, Young Jae Kim, Kwang Gi Kim, Vincenzo De Luca
    PLOS ONE.2019; 14(6): e0217639.     CrossRef
  • Association of alcohol and drug use with use of electronic cigarettes and heat-not-burn tobacco products among Korean adolescents
    Yeji Lee, Kang-Sook Lee, Hajo Zeeb
    PLOS ONE.2019; 14(7): e0220241.     CrossRef
Association between Alcohol Intake and Abdominal Obesity among the Korean Population
Mikyung Ryu, Heejin Kimm, Jaeseong Jo, Sun Ju Lee, Sun Ha Jee
Epidemiol Health. 2010;32:e2010007.   Published online May 19, 2010
DOI: https://doi.org/10.4178/epih/e2010007
  • 17,384 View
  • 115 Download
  • 14 Crossref
AbstractAbstract PDF
Abstract
<sec><title>OBJECTIVES</title><p>Although abdominal obesity has been reported to be highly related with alcohol intake, the results are still inconclusive. Therefore, this study was conducted to explore the association between alcohol and abdominal obesity among the Korean population.</p></sec><sec><title>METHODS</title><p>This study included 8,603 participants (men: 5,195, women: 3,408) aged 30 to 87 who visited the health promotion centers in Seoul for routine health examinations from April, 2006 to June, 2007. Abdominal obesity was defined as WC ≥90 cm for men and ≥85 cm for women in accordance with the Korean Society for the Study of Obesity. For ever drinkers, total alcohol consumption in grams was classified into four groups (group 1, non-drinkers; group 2, 1-10 g of alcohol per day; group 3, 11-20 g of alcohol per day; and group 4, over 20 g of alcohol per day).</p></sec><sec><title>RESULTS</title><p>The mean age of the study population was 45.4 yr old (men) and 45.3 yr (women). The average waist circumference was 85.3 cm in men and 75.3 cm in women. A high alcohol intake was associated with high waist circumference in both genders. In multivariate analysis, the group of men and women drinkers consuming >20 g in a day had a large waist circumference compared with men and women non-drinkers.</p></sec><sec><title>CONCLUSION</title><p>This study showed that a high alcohol intake was related to high waist circumference. Such association remained independently even after adjustment for smoking, which is strongly related to abdominal obesity.</p></sec>
Summary

Citations

Citations to this article as recorded by  
  • Measuring Racial Differences in Obesity Risk Factors in Non-Hispanic Black and White Men Aged 20 Years or Older
    Hossein Zare, Aida Aazami, Noran Shalby, Danielle R. Gilmore, Roland J. Thorpe
    American Journal of Men's Health.2023;[Epub]     CrossRef
  • Dietary Intervention in Glaucoma
    Syed Shoeb Ahmad, Syed Mohammed Bilal, Anam Tariq, Aliya Rashid
    US Ophthalmic Review.2022; 16(1): 22.     CrossRef
  • Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal study
    Jiaru Sun, Xiaoqin Wang, Paul D Terry, Xiaohan Ren, Zhaozhao Hui, Shuangyan Lei, Caihua Wang, Mingxu Wang
    BMJ Open.2022; 12(7): e061261.     CrossRef
  • Relationship between Obesity and Lifestyle Factors in Young Korean Women: the Seventh Korea National Health and Nutrition Examination Survey 2016
    Jeon Won Kwak, Chan Hee Jeon, Min Ho Kwak, Jeong Hyeon Kim, Yong Soon Park
    Korean Journal of Health Promotion.2019; 19(1): 9.     CrossRef
  • Predictors of overweight/obesity in a Brazilian cohort after 13 years of follow-up
    Ludimila Garcia Souza, Thiago Veiga Jardim, Ana Carolina Rezende, Ana Luiza Lima Sousa, Humberto Graner Moreira, Naiana Borges Perillo, Samanta Garcia de Souza, Weimar Kunz Sebba Barroso de Souza, Ymara Cássia Luciana Araújo, Maria do Rosário Gondim Peixo
    Nutrition Journal.2018;[Epub]     CrossRef
  • Acute High-Dose and Chronic Lifetime Exposure to Alcohol Consumption and Differentiated Thyroid Cancer: T-CALOS Korea
    Yunji Hwang, Kyu Eun Lee, Elisabete Weiderpass, Young Joo Park, Young Jun Chai, Hyungju Kwon, Do Joon Park, BeLong Cho, Ho-Chun Choi, Daehee Kang, Sue K. Park, Li Wang
    PLOS ONE.2016; 11(3): e0151562.     CrossRef
  • Lifestyle Risk Factors of General and Abdominal Obesity in Students of the School of Medicine and Health Science of the University of Development Studies, Tamale, Ghana
    Victor Mogre, Rauf Nyaba, Samuel Aleyira
    ISRN Obesity.2014; 2014: 1.     CrossRef
  • Factors associated with central overweight and obesity in students attending the University for Development Studies in Tamale, Ghana: a cross-sectional study
    V. Mogre, S. Aleyira, R. Nyaba
    South African Journal of Clinical Nutrition.2014; 27(2): 69.     CrossRef
  • Trends in the Incidence of Subarachnoid Hemorrhage in South Korea from 2006–2009: An Ecological Study
    Jin-Won Kwon, Hyun Joo Lee, Min Kyung Hyun, Ji Eun Choi, Jong Hee Kim, Na Rae Lee, Jin Seub Hwang, Eun Ju Lee
    World Neurosurgery.2013; 79(3-4): 499.     CrossRef
  • Adiponectin negatively correlates with alcoholic and non‐alcoholic liver dysfunction: Health check‐up study of Japanese men
    Mina Hamano, Yoshihiro Kamada, Shinichi Kiso, Kunimaro Furuta, Takashi Kizu, Norihiro Chatani, Mayumi Egawa, Takayo Takemura, Hisao Ezaki, Yuichi Yoshida, Kenji Watabe, Toshimitsu Hamasaki, Miyuki Umeda, Aiko Furubayashi, Kazuo Kinoshita, Osamu Kishida, T
    Hepatology Research.2013; 43(3): 238.     CrossRef
  • Alcohol Consumption Patterns and Body Weight
    C. Dumesnil, L. Dauchet, J.B. Ruidavets, A. Bingham, D. Arveiler, J. Ferrières, P. Ducimetière, B. Haas, V. Bongard, A. Wagner, P. Amouyel, J. Dallongeville
    Annals of Nutrition and Metabolism.2013; 62(2): 91.     CrossRef
  • Rupture rate for patients with untreated unruptured intracranial aneurysms in South Korea during 2006–2009
    Eun Ju Lee, Hyun Joo Lee, Min Kyung Hyun, Ji Eun Choi, Jong Hee Kim, Na Rae Lee, Jin Seub Hwang, Jin-Won Kwon
    Journal of Neurosurgery.2012; 117(1): 53.     CrossRef
  • Global Gender Disparities in Obesity: A Review
    Rebecca Kanter, Benjamin Caballero
    Advances in Nutrition.2012; 3(4): 491.     CrossRef
  • Relationship between obesity, alcohol consumption, and physical activity of male office workers in South Korea
    Oksoo Kim, Hae Ok Jeon
    Nursing & Health Sciences.2011; 13(4): 457.     CrossRef
Epidemiol Health : Epidemiology and Health
© Korean Society of Epidemiology.